Evaluation of p53 mutations in premalignant esophageal lesions and esophageal adenocarcinoma using laser capture microdissection
نویسندگان
چکیده
منابع مشابه
Larynx and Esophageal Lesions in Herpetic Disease
Les Lesions Laryngees et oesophayiennes de la maladie herpetique ant ete decrit recemment sur 5 cas (Annales de radiologie). Ces lesions ont evolue vers une stenose organique de l'oesophage dans 3 cas. L'aspzct radiologique de ces stenoses et lear evolution sont tres pronches des stenoses caustiques. Un cas personnel de stenose oesophagienne de Ce meme type, 3 ans apres une episode aigue ...
متن کاملLaser Therapy of Esophageal Carcinoma
SUMMARY 13 Consecutive patients who underwent endoscopic Nd - Y AG laser therapy for palliation of advanced esophageal cardnoma were treated between Oct 1989, and July 1991 , in Khatam - al -Anbia Hospital. All patients had severe dysphagia and conventional methods such as surgery , Radiotherapy and chemotherapy failed to treat them. Undoubtedly without laser therapy these patients did not see...
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Efficient detection of somatic mutations is important for the development of clinical molecular diagnostic assays. However, the detection of somatic mutations in tissue is confounded by dilution of the tumor cell population by normal cells. Laser microdissection allows enrichment for tumor-associated genetic alterations to take place at the level of cell selection, eliminating the need to enric...
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Laser-capture microdissection is a recently discovered state-of-the-art method to obtain cells for genetic analysis. It is a one-step procedure that allows capture of selected cells under direct microscopic visualization.
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Laser capture microdissection (LCM) allows for the microscopic procurement of specific cell types from tissue sections that can then be used for gene expression analysis. According to the recent development of the LCM technologies and methodologies, the LCM has been used in various kinds of tissue specimens in dental research. For example, the real-time polymerase-chain reaction (PCR) can be pe...
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ژورنال
عنوان ژورنال: Modern Pathology
سال: 2004
ISSN: 0893-3952,1530-0285
DOI: 10.1038/modpathol.3800231